This is likely an over-simplification, but it is more straightforward than a long description. FOSSILIONTECHS’ core technologies are nanoElectrospray, Secondary Electrospray, and all that is related to Ion Mobility and Mass Spectrometry solutions. Their key products are:
– SUPER SESI, an ionization source optimized for the analysis of volatile and semi-volatile organic compounds in real-time. This unique source has users worldwide.
– nanoESI emitters, the Sharp Singularity, high quality, and cost-effective nano ESI emitters with a clear mission: never again compromise the quality of your experiment because of an old and unstable tip. For this, FOSSILIONTECH re-engineered the way emitters are produced to achieve very sharp emitters with tight tolerances at the best prices.
Here is a detailed cross reference table of the tips produced by FOSSILIONTECH and the sources they fit.
We will keep stock of 2cm tips (for Bruker Cpative Spray), 3cm tips (NTA-FIS on a QE), 4cm (NTA-FIS on LTQ/LUMOS) and 5cm (PharmaFluidics FlexiON Connect). All others available on order.
Why sharper emitters are better:
The minimum wetting contact angle an emitter can accommodate is limited by its sharp angle. In addition, the strength of the electrostatic fields tangent to the surface of the emitter depends on the sharpening angle of the emitter. This electrostatic force keeps the meniscus centered and aiming straight by compensating for the effect of the surface tension, which pushes the liquid to climb backwards. If this component is not strong enough, the spray starts dripping and becomes unstable. Sharper emitters produce more stable sprays because the tangent component of the electrostatic field is stronger. The result is that sharper emitters can accommodate a wider range of local electric fields (voltages), surface tensions and wetting contact angles.
Why the inner diameter has to be small:
Combined with μ-LC and n-LC and, smaller diameters have faster responses, and hence better chromatography separation. Smaller diameters lead to lower evaporation rates at the meniscus of the n-ESI, better n-ESI ionization efficiencies, and better detection limits in proteomic workflows. Smaller diameters require lower voltages and delay the onset of discharges, which also leads to more stable sprays. On the other hand, smaller diameters are more prone to clogging, and age more rapidly. Normal IDs range from 10μm to 50μm. The choice of ID of the emitters is a trade-off decision, between performance and robustness.